Ozempic® - Frequently Asked Questions

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 Ozempic is a brand-name drug made by Novo Nordisk. The generic name is Semaglutide, the same ingredient used in Wegowy, made also by Noco Nordisk, which is approved for weight loss. 

The difference between Wegowy and Ozempic is the higher concentration of Semaglutide in Wegowy. Ozempic and Wegowy, in other words, both contain Semaglutide, just different concentrations of it. Semaglutide is a class GLP 1 agonist (glucagon-like peptide 1 receptor agonist). These receptors are found in our digestive system. So, the drug attaches to receptors and causes the pancreas to produce insulin. 

 The effects of this drug consist of two things:

1. Food moves through the digestive tract much slower, making us feel full longer. 
2. The insulin travels to the hypothalamus (part of the brain) and gives it a signal of satiety, so we again feel full. 

As a diabetic drug, it can be taken long-term. We are talking years. 

 Patients report feeling more energetic while on Semaglutide, without feeling hunger or starvation. 

There are few. Most patients experience common side effects such as nausea, vomiting, diarrhea, and constipation (as the food moves slowly through the intestines). To counteract these adverse effects, we gradually increase the dosage to let our bodies adjust. We also recommend that patients drink ample amounts of water. Water helps our bodies process the food we eat and prevents constipation.

Patients with end-stage kidney disease, a history of pancreatitis, diabetic retinopathy, and a family history of thyroid cancer should avoid this treatment.  For more complete details, please review the information provided by the Mayo Clinic.

Semaglutide injection may increase the risk that you will develop thyroid gland tumors, including medullary thyroid carcinoma (MTC; a type of thyroid cancer). Laboratory animals given semaglutide developed tumors, but it is unknown if this medication increases the risk of tumors in humans.

There is not enough data regarding how semaglutide interacts with the embryo and fetus during pregnancy, or while breastfeeding; therefore, it is not recommended to use while pregnant or breastfeeding. 

Weekly injection into the abdomen area using an insulin syringe.

The best approach is to use semaglutide as an aid. It is a helpful way to regulate your caloric intake and should be combined with regular exercise and a healthy diet. 

We advise patients to taper off their dosage when planning to stop injections.  Remember that semaglutide is just one part of overall weight loss management. Maintain healthy diet choices and exercise. 

Speaking with your family physician before starting new medications or weight loss programs is always recommended. Regular blood tests, including calcitonin levels. 

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